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. 2021 Jan 14;121(3):1746–1803. doi: 10.1021/acs.chemrev.0c00779

Table 1. Overview of Studies Employing ciRGD for Enhanced Tumor Delivery of Nanoparticles.

cancer type NM composition material hydrodynamic diameter (nm) iRGD administration ref
human breast cancer (BT474) and human prostate cancer (22Rv1) iRGD–ABX (conjugated) albumin and doxorubicin liposomes 130/120 nm conjugated or coadministration (194)
  iRGD+ABX (combination)        
  DOX liposomes+iRGD (combination)        
             
pancreatic ductal adenocarcinoma (PDAC) irinotecan-loaded silicasome silicasome 130 nm coadministration (201)
             
murine breast cancer (4T1) IDDHN, hyaluronic acid (HN) shell dendrimer 35–150 nm coadministration (198)
  +dendri-graft-l-lysine conjugated with doxorubicin and indocyanine (IDD)        
             
murine breast cancer (4T1) iRGD/AuNPs-A&C gold   coadministration (413)
             
murine breast cancer (4T1) iNP/IT lipid-polymer hybrid 112 nm conjugated (199)
  (iRGD-conjugated NP        
  loaded with ICG and TPZ)        
             
human liver cancer (HepG2) DOX+SOR/iRGD NPs lipid-polymer hybrid 126 nm conjugated (202)
             
murine colon cancer (colon-26) iRGD-PEG-NPs polymeric 280 nm conjugated (203)
  (CPT-loaded)        
             
human colon cancer (lovo-6-luc-1) /human gastric cancer (MKN45)/ iRGD/DOX liposomes not reported coadministration (204)
human ovarian cancer (IGROV-1)          
             
human ovarian cancer (OVCAR-8) /human schwannoma (HEI-193) iRGD-transportan-siRNA peptides/siRNA 80 nm conjugated (205)
             
human breast cancer (MCF10CA1a) /pancreatic ductal adenocarcinoma (KRAS-Ink) /human prostate cancer (PC-3) ZHA-QDs quantum 12 nm coadministration (207)
           
    dots      
             
human prostate cancer (PC3-MM2) Psi-NPs silicon 202 nm conjugated (209)
             
murine breast cancer (4T1) iRGD-NDs iRGD-NPs carbon ND = 10 nm conjugated (200)
      NP = 70 nm    
             
pregnancy complications FAM-iRGD iron oxide 180 nm conjugated (206)
    nanoworms      
             
pregnancy complications liposome-iRGD liposomes 146 nm conjugated (206)