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. 2021 Jan 15;12(2):211–216. doi: 10.1021/acsmedchemlett.0c00527

Table 1. Inhibitory Activity against rhIDO1 and Cellular Kynurenine Production by Carbonothioate (4a, 4b).

graphic file with name ml0c00527_0007.jpg

cpd R1 rhIDO1 IC50 (μM) KYNa % inhibition cytotoxb IC50 (μM)
4a (CH2)2Ph 0.94 44% @10 μM >20
4b H 4.2 50% @10 μM >20
a

Kynurenine production in A431 cells.

b

Cytotoxicity to A431 cells.