Table 3. Oral Pharmacokinetic Profiles of Compound 14 and 18.
| rat
PK@3mg/kg |
dog
PK@2mg/kg |
|||||
|---|---|---|---|---|---|---|
| compd | Cmax (ng/mL) | AUC (ng/mL·h) | t1/2 (h) | Cmax (ng/mL) | AUC (ng/mL·h) | t1/2 (h) |
| 14 | 173 | 1034 | 5.08 | 140 | 255 | 1.10 |
| 18 | 179 | 1527 | 6.14 | 742 | 3633 | 3.04 |
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