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. 2021 Jan 15;12(2):202–210. doi: 10.1021/acsmedchemlett.0c00460

Scheme 2. Synthesis of C2-Symmetric Cyclic Sulfamide 34.

Scheme 2

Methyl (S)-2-hydroxy-4-methylpentanoate, PPh3, DIAD, THF.

BnCl or BnBr, K2CO3, CH3CN.

TFA, CH2Cl2.

BnCl or BnBr, K2CO3, CH3CN.

LiAlH4, THF.

Oxalyl chloride, DMSO, Et3N, CH2Cl2,-78 °C.

Ph3P+CH3Br, n-BuLi, THF.

Grubbs Catalyst-II, benzene, reflux.