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. 2021 Feb 1;11:624122. doi: 10.3389/fendo.2020.624122

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Copyright © 2021 Odagiu, May, Boulet, Baldwin and Labrecque

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Function of the NR4A family in thymocyte development. TCR stimulation induces expression of the NR4A family. In the nucleus, NR4As can regulate the expression of genes that control T cell tolerance. Additionally, NR4A family members can be exported from the nucleus where they directly regulate apoptosis through an interaction with Bcl-2.