Table 1.

Role of NR4A family members in CD8 T cells.

Expression	Nr4a1	Nr4a2	Nr4a3	References
Rapid and transient induction by in vitro TCR stimulation	✓	✓	✓	(42, 85–90)
Rapid and transient induction during in vivo acute response	✓	✓	✓	(42, 87, 89, 91)
Constitutive expression by resident memory T cells	✓	✓	✓	(92–95)
High expression by exhausted T cells	✓	✓	✓	(47, 48, 67, 96–99)
Function	NR4A1	NR4A2	NR4A3	References
T cell proliferation	ê	N.D.	No effect	(68, 88, 89)
Cytokine production	ê	N.D.	ê	(67, 68, 88, 89)
SLEC differentiation	ê or no effect	N.D.	é	(68, 88, 89)
MPEC differentiation	é or no effect	N.D.	ê	(66, 88, 89)
Central memory T cell generation	No effect	N.D.	ê	(89, 100)
Resident memory T cell generation	é	é	é	(94, 95, 100)
T cell exhaustion	é	é	é	(48, 67, 88, 89)
Molecular mechanism	NR4A1	NR4A2	NR4A3	References
Competition for bZIP transcription binding activity	✓	N.D.	✓	(67, 89)