Table 2.

Role of NR4A family members in CD4 T cells.

Expression	Nr4a1	Nr4a2	Nr4a3	References
Rapid and transient induction by in vitro TCR stimulation	✓	✓	✓	(38, 69, 74, 87, 88, 90, 112)
Th1	Low	Low	Low	(113)
Th2	Low	Low	Low	(113)
Th17	Low	Low	Low	(113)
Tfh	✓ or low	✓ or low	Low	(112, 113)
T reg	✓	✓	✓	(113)
Dysfunctional/exhausted or tolerant CD4 T cells	✓or low	✓or low	✓	(88, 96, 97)
Function	NR4A1	NR4A2	NR4A3	References
T cell proliferation	ê	N.D.	N.D.	(69)
Cytokine production	ê	é	N.D.	(69, 88, 114)
Th1 polarization	ê	ê or no effect	N.D.	(69, 74, 88, 115)
Th2 polarization	No effect	N.D.	N.D.	(88)
Th17 polarization	ê	ê or é	N.D.	(69, 74, 88, 115)
iTreg differentiation Treg identity	No effect é	é é	N.D. é	(74, 88) (113)
Tfh development and function in vivo	No effect in TKO	No effect in TKO	No effect in TKO	(112)
T cell tolerance	é	N.D.	N.D.	(88)
Molecular mechanism	NR4A1	NR4A2	NR4A3	References
Competition for bZIP transcription binding activity	✓	N.D.	N.D.	(88)