Table 1.
Data collection statistics for IR models
| Training data | Testing data | |||
|---|---|---|---|---|
| Study types | Positive (N1) | Negative (N2) | Positive (N3) | Negative (N4) |
| DDI | ||||
| In-vitro PK | 150* | 10,000 | 150* | 800† |
| Clinical PK | ||||
| Clinical PD | ||||
| DGI | 1,700 | 1,700 | 1,729 | 8,300 |
IR: information retrieval, PK: pharmacokinetics, PD: pharmacodynamics, DGI: drug-gene interactions
*
The 150 abstracts were different for training and testing as well as each of the in-vitro PK, clinical PK, and clinical PD DDI studies
†
Among 800 negative abstracts, 500 were single-drug or nutrition-related abstracts and 300 were randomly selected abstracts