Table 1.
Polygenic Risk Score Compositions1, 2
| Marker | Gene | Risk Allele (Freq) | Chr | Position |
|---|---|---|---|---|
| TBBMD PRS | ||||
| rs452369 | SLC8A1 | A(0.24) | 2 | 40,157,593 |
| rs529125 | SUPT3H | A(0.87) | 6 | 44,829,351 |
| rs2800718 | LOC105377989 | A(0.21) | 6 | 127,079,180 |
| rs10953178 | SEM1 | G(0.36) | 7 | 96,501,326 |
| rs950083 | C(0.74) | 10 | 122,717,980 | |
| rs12273330 | DGKZ | A(0.03) | 11 | 46,340,356 |
| rs4394609 | A(0.93) | 1 | 22,406,025 | |
| rs914153 | A(0.70) | 21 | 38,980,535 | |
| rs370055571 | MAP 4 K3 | A(0.01) | 2 | 39,258,582 |
| LBBMD PRS | ||||
| rs9846561 | LEKR1 | A(0.96) | 3 | 157,040,993 |
| rs16934799 | KCNMA1 | A(0.98) | 10 | 77,448,298 |
| rs2087058 | LOC105369777 | G(0.54) | 12 | 54,199,621 |
| rs1286083 | RPS6KA5 | G(0.12) | 14 | 90,976,435 |
| rs7071206 | A(0.75) | 10 | 77,641,558 | |
| rs6684375 | G(0.90) | 1 | 22,379,941 | |
1 Polygenic Risk Score includes SNPs that are statistically significant or nominally significant associated with BMD in Viva La Familia Study
2 BMD bone mineral density, DGKZ Diacylglycerol Kinase Zeta, PRS Polygenic Risk Score, KCNMA1 Potassium Calcium-Activated Channel Subfamily M Alpha 1, LEKR1 Leucine, Glutamate and Lysine Rick 1, MAP 4K3 Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3, RPS6KA5 Ribosomal Protein S6 Kinase A5, SEM1 26S Proteasome Complex Subunit, SLC8A1 Solute Carrier Family 8, SUPT3H SPT3 Homolog, SAGA and STAGA Complex Component