Table 3.
Interaction between PRS and moderate to vigorous physical activity on TBBMD and LSBMD 1,2,3
| Marker | β_G4 | Pvalue_G | β_Interaction5 | Pvalue_Interaction |
|---|---|---|---|---|
| Polygenic Risk Scores | ||||
| TBBMD | ||||
| TBBMD_PRS, cat | −0.5 | 5.9 × 10−5 | 0.37 | 0.0047 |
| LSBMD | ||||
| TBBMD_PRS, cat | −0.45 | 1.8 × 10−5 | 0.36 | 0.0011 |
| Individual SNPs | ||||
| TBBMD | ||||
| rs10953178 | −0.29 | 7.6 × 10−4 | 0.22 | 0.046 |
| rs914153 | −0.21 | 5.5 × 10−3 | 0.2 | 0.028 |
| LSBMD | ||||
| rs452369 | −0.38 | 5.6 × 10−6 | 0.24 | 0.038 |
| rs10953178 | −0.26 | 1.5 × 10− 3 | 0.27 | 0.0074 |
| rs914153 | −0.23 | 6.2 × 10−4 | 0.24 | 0.0058 |
1 Only results with statistically significant interactions are shown (p value for interaction< 0.05)
2 Adjusted for age, sex, BMI Z-score, and puberty stage
3 PRS Polygenic Risk Score, LSBMD lumbar spine bone mineral density, TBBMD total body bone mineral density; TBBMD_PRS, cat TBBMD unweighted PRS, categorized by median (> = median vs below)
4 β_G, beta coefficients for main effects of PRS
5 β_Interaction, beta coefficients for interaction effects between PRS and MVPA