Table 2.

Results of linear regression analyses for neuropsychological tests and atrophy score

	β per SD (95% CI)	p value	Partial η2
Memory score
Serum NfL	− 0.27 (− 0.56–0.02)	0.067	0.0096
Serum tau	0.10 (− 0.17–0.37)	0.46	0.0016
Speed score
Serum NfL	− 0.41 (− 0.74–0.08)	0.014	0.017
Serum tau	0.04 (−0.27–0.35)	0.8	0.00018
Motor score
Serum NfL	− 0.46 (− 0.70–0.21)	< 0.001	0.036
Serum tau	0.01 (− 0.22–0.25)	0.92	0.000031
CASCADE score
Serum NfL	− 1.15 (− 1.83–0.47)	< 0.001	0.031
Serum tau	0.14 (− 0.50–0.78)	0.66	0.00056
Atrophy score
Serum NfL	0.34 (0.05–0.64)	0.023	0.02
Serum tau	0.17 (− 0.13–0.47)	0.27	0.0048
Subcortical atrophy at the level of the anterior ventricular horns
Serum NfL	0.001 (− 0.004–0.006)	0.64	0.00084
Serum tau	0.005 (0.00002–0.009)	0.049	0.015

All analyses were adjusted for age, sex, education, and any comorbidities. Partial η² ≥ 0.01: small effect size. Partial η² ≥ 0.06: medium effect size. Partial η² ≥ 0.14: strong effect size