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. 2021 Jan 27;12(2):295–301. doi: 10.1021/acsmedchemlett.0c00674

Table 1. Dipeptide Amino Acid Sequence Study.

graphic file with name ml0c00674_0004.jpg

compd. AA1 AA2 % inhibitiona
1 Ile Leu 100
2 Ile Phe 100
3 Ile Ile 85
4 Ile Aib 84
5 Ala Ile 55
6 Phe Ile 44
7 Ile Ala 31
8 Aib Ile 11
9 Ile* Ile* 48
10 Ile* Ile 57
11 Ile Ile* 69
12 Ile* Phe* 63
13 Phe Ile* 62
14 Ile Phe* 41
15 β-Ala Ile 62
16 Gly Ile 18
a

Dipeptides were evaluated at 15 μM with 20 nM BoNT/A LC and 8 μM SNAPtide substrate. Enzyme reactions were performed in triplicate, and the percent inhibition reported is the average. *d-amino acid.