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. 2021 Jan 27;12(2):295–301. doi: 10.1021/acsmedchemlett.0c00674

Table 2. Probing the Aromatic System on the Dipeptide N-Terminus.

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compd. R % inhibitiona
17 biphenyl 77
18 4-cyclohexylphenyl 57
19 phenyl 52
20 3,5-dichlorophenyl 100
21 meta-tert-butylphenyl 93
22 para-bromophenyl 87
23 para-chlorophenyl 77
24 meta-chlorophenyl 79
25 3,4-diethoxyphenyl 22
26 2,6-dichlorophenyl 83
a

Dipeptides were evaluated at 15 μM with 20 nM BoNT/A LC and 8 μM SNAPtide substrate. Enzyme reactions were performed in triplicate, and the percent inhibition reported is the average.