. 2021 Jan 6;12(2):249–255. doi: 10.1021/acsmedchemlett.0c00612

Table 1. Measured Activities in the Enzyme Inhibition (IC₅₀) and Infected T-Cell Assays (EC₅₀), and Cytotoxicity (CC₅₀).

compd	IC₅₀ (nM)^a	EC₅₀ (nM)^b	CC₅₀ (μM)^c
1	3.0	0.055	10
2	4900	>50000	50
3	833	9200	78
4	103	280	66
5	246	320	40
6	82.3	58	62
7	14.7	37	15
8	164	5	75
9	64	7	55
10	42.4	26	26
11	150	270	42
12	119	160	45
13	ND	14000	100
14	5000	17000	90
15	375	2700	60
nevirapine	1060	110	>100
rilpivirine	38	0.67	8

For 50% inhibition of reverse transcription (nM).

For 50% protection in MT-2 cells (nM).

For 50% inhibition of MT-2 cell growth (μM).

Table 1. Measured Activities in the Enzyme Inhibition (IC50) and Infected T-Cell Assays (EC50), and Cytotoxicity (CC50).