Table 1. Structure–Activity Relationships of the A Ring.

^aAntiviral effects of compounds. After 5 days of incubation with the compounds, HBV DNA was purified from the HepG.2.2.15 cell culture supernatants and subjected to real-time PCR.

^bCytotoxicity of compounds determined by cell viability assays after incubating HepG2.2.15 cells with compounds. Data are shown as the mean ± SD of three independent experiments. n.d.: not determined.