Table 3. In Vivo Pharmacokinetic Parameters of Compounds 3 and 8 in SD Male Rats^a.

	3		8
parameterb	I.V. (5 mg/kg)c	P.O. (5 mg/kg)d	I.V. (5 mg/kg)c	P.O. (5 mg/kg)d
Tmax (h)	N/A	1.67 ± 2.02	N/A	1.33 ± 0.58
Cmax (μg/mL)	N/A	0.48 ± 0.39	N/A	0.28 ± 0.15
T1/2 (h)	1.22 ± 0.07	3.84 ± 0.20	2.55 ± 0.33	5.16 ± 1.16
AUClast (μg·h/mL)	2.45 ± 0.51	2.08 ± 0.33	2.31 ± 0.15	1.15 ± 0.53
AUC∞ (μg·h/mL)	2.50 ± 0.48	2.10 ± 0.32	2.33 ± 0.15	1.23 ± 0.57
CL (L/h/kg)	2.05 ± 0.40	N/A	2.16 ± 0.14	N/A
Vss (L/kg)	2.88 ± 0.85	N/A	3.59 ± 0.82	N/A
Ft (%)	N/A	84.17	N/A	49.94

^aDetailed pharmacokinetics of compounds 3 and 8 are described in Supporting Information.

^bValues are shown as the mean ± standard deviation of at least three independent experiments.

^cParameters from intravenous administration.

^dParameters from oral administration.