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. 2021 Jan 15;12(2):217–227. doi: 10.1021/acsmedchemlett.0c00554

Table 1. Hit Compounds Identified after First Round Screen.

compound no. 1 2 3
LasB Ki (μM) 18.1 6.87 14.8
ACE Ki (μM) >57 >57 >57
follow-ups identified 15 91 47
follow-ups selected and tested 10 36 18
follow-ups withLasB inhibition >40% @ 30 μM 3 9 2