. 2021 Jan 28;12(2):288–294. doi: 10.1021/acsmedchemlett.0c00668

Table 4. Pharmacokinetic Parameters for BMS-986242 (25).

parameter	mouse^a	rat^a	dog^a	cyno^a
dose (mg/kg) iv/po	0.5^b/6^c	0.5^b/2^c	1^b/5^c	1^b/5^c
CL (mL/min/kg) iv	30	3.70	5.1	12
Vss (L/kg) iv	17	0.97	3.87	1
AUC_total (μM·h) iv/po	0.69/12.6	5.6/28.2	8.7/17.4	3.4/7.1
t_1/2 (h) iv	8	4	19	2
F_po (%)	152	127	39	42

Data reported as average of ≥3 animals.

70% PEG 400; 30% water.

5% ethanol; 55% PEG 400; 20% propylene glycol; 20% TPGS.