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. 2021 Jan 28;12(2):288–294. doi: 10.1021/acsmedchemlett.0c00668

Table 4. Pharmacokinetic Parameters for BMS-986242 (25).

parameter mousea rata doga cynoa
dose (mg/kg) iv/po 0.5b/6c 0.5b/2c 1b/5c 1b/5c
CL (mL/min/kg) iv 30 3.70 5.1 12
Vss (L/kg) iv 17 0.97 3.87 1
AUCtotal (μM·h) iv/po 0.69/12.6 5.6/28.2 8.7/17.4 3.4/7.1
t1/2 (h) iv 8 4 19 2
Fpo (%) 152 127 39 42
a

Data reported as average of ≥3 animals.

b

70% PEG 400; 30% water.

c

5% ethanol; 55% PEG 400; 20% propylene glycol; 20% TPGS.