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Effect of C-terminal and N-terminal cleavage on receptor binding and biological functions of GIP
| Effect | GIP(1–42) | GIP(3–42) | GIP(1–30) | GIP(3–30) | Ref. |
|---|---|---|---|---|---|
| GIP Receptor binding | High | Low | High | High | Hansen et al. (2016) |
| Receptor activity | Agonist | Weak antagonist | Agonist | Strong antagonist | Hansen et al. (2016) |
| cAMP production | Increase | Decrease | Increase | Decrease | Kerr et al. (2011) |
| Insulin secretion | Increase | Decrease | Increase | Decrease | Kerr et al. (2011), Sparre-Ulrich et al. (2017) |
