Table 6.
Receptor selectivity and effect on food intake of intact and cleaved PYY
Intact PYY(1–36) | Cleaved PYY(3–36) | Ref. | |
---|---|---|---|
Receptor selectivity | Y1, Y2, Y4, and Y5 agonist | Y2 agonist | Grandt, Schimiczek, Beglinger, et al. (1994) |
Food intake | Decrease (no effect on DPP4-deficient mice) | Decrease (acts on DPP4-deficient mice) | Batterham et al. (2003), Chelikani et al. (2005), Moran et al. (2005), Pittner et al. (2004), Tschop et al. (2004) |