Table 7.
Receptor selectivity and effect on cell migration and food intake of intact and cleaved NPY
Intact NPY(1–36) | Cleaved NPY(3–36) | Ref. | |
---|---|---|---|
Receptor selectivity | Y1, Y2, Y4, and Y5 agonist | Y2 agonist | Grandt et al. (1996) |
Cell migration | + (effect blocked with DPP4 inhibition) | +(effect retained with DPP4 inhibition) | Ghersi et al. (2001) |
2 Hour food intake | + | ++ | Flynn et al. (1998) |