TABLE 2.

Month 3 protein Level Comparison: Discovery (CTOT14) and Validation (BUMC) Cohorts

	CTOT14 (Predict 1 Year) Plasma			BUMC (Predict 1 and 5 Year) Sera
	Diminished	Preserved	P Value	Diminished	Preserved	P Value
β-2 microglobulin (μg/mL)	3.75 [2.58; 5.32]	2.55 [2.20; 3.70]	0.011	4.25 [3.70; 5.42]	3.15 [2.35; 3.92]	0.002
Cystatin C (ng/mL)	1,325 [1,222; 1,872]	1,105 [1,028; 1,322]	0.004	1,435 [1,282; 1,578]	1,085 [896; 1,350]	0.001
Macrophage colony stimulating factor 1 (ng/mL)	0.94 [0.66; 1.60]	0.90 [0.66; 1.22]	0.694	2.15 [1.80; 2.92]	1.50 [0.83; 2.20]	0.007
α-1 microglobulin (μg/mL)	23.0 [15.8; 29.0]	18.5 [15.0; 24.0]	0.135	24.0 [21.2; 29.8]	21.0 [15.8; 24.0]	0.007
CD40 antigen (ng/mL)	0.94 [0.72; 1.50]	0.94 [0.76; 1.42]	0.911	1.50 [1.30; 1.70]	1.10 [0.98; 1.40]	0.001
Erythropoietin (mIU/mL)	18.0 [14.0; 32.2]	15.5 [9.67; 23.0]	0.099	33.0 [24.0; 38.5]	23.5 [19.8; 29.0]	0.041
Apolipoprotein A-IV (μg/mL)	3,850 [3,640; 5,520]	5,100 [4,052; 7,350]	0.113	49.5 [38.5; 64.2]	40.5 [33.8; 61.8]	0.189
Clusterin (μg/mL)	256 [234; 297]	271 [228; 349]	0.382	262 [208; 283]	212 [184; 237]	0.027
Kim-1 (ng/mL)	0.08 [0.05; 0.12]	0.12 [0.09; 0.23]	0.065	0.10 [0.07; 0.20]	0.08 [0.04; 0.11]	0.067
Neutrophil gelatinase-associated lipocalin (ng/mL)	280 [177; 425]	220 [172; 270]	0.095	391 [234; 484]	294 [223; 378]	0.176
Osteopontin (ng/mL)	42.0 [35.5; 62.5]	37.5 [34.0; 48.0]	0.187	25.5 [17.2; 30.0]	21.0 [11.8; 25.2]	0.056
Tamm-Horsfall protein (μg/mL)	0.03 [0.02; 0.04]	0.02 [0.02; 0.03]	0.588	0.03 [0.03; 0.04]	0.04 [0.03; 0.05]	0.117
Tissue inhibitor of metalloproteinases 1 (ng/mL)	114 [84.8; 153]	97.0 [84.8; 118]	0.187	154 [137; 184]	146 [123; 166]	0.122
Trefoil factor-3 (μg/mL)	0.20 [0.14; 0.26]	0.16 [0.13; 0.20]	0.045	0.15 [0.12; 0.20]	0.12 [0.10; 0.15]	0.037
Vascular endothelial growth factor (pg/mL)	94.0 [81.5; 133]	92.5 [75.8; 122]	0.386	256 [192; 355]	298 [188; 400]	0.864
Thrombomodulin (ng/mL)	7.15 [5.28; 8.90]	6.55 [4.80; 7.23]	0.157	7.20 [6.70; 9.10]	6.50 [5.15; 7.82]	0.037