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. 2020 Dec 16;37(4):e2020009. doi: 10.36141/svdld.v37i4.10726
Site: Netherlands
Covid Positive Covid negative Percent with feature Percent COVID positive Hazard s ratio 95% CI P Comments
Sarcoidosis (996 who live in the Netherlands , out of 1034 respondents ) 23 973 996 2.31%
Male 6 418 424 21.60% 1.42% 0.4745 0.1187-1.1932 >0.10
Female 17 553 570 29.04% 2.98% 2 no sex indicated
White 22 932 954 48.60% 2.31% 0.9682 0.1337-7.0165 >0.10
Other 1 41 42 2.14% 2.38%
BMI categories
BMI < 25 8 348 356 18.14% 2.25% 0.958 0.4029-2.2323 >0.10
BMI ≥ 25 15 623 638 32.50% 2.35%
Current meds
Prednisone 4 194 198 10.09% 2.02% 0.84585 0.2919-2.4661 >0.01 of 28 patients the dose is missing
No prednisone 19 779 987 40.65% 2.38%
Prednisone ≥ 10 mg 2 76 78 3.97% 2.56% 1.1795 0.1701-8.1803 >0.10
Prednisone < 10mg 2 90 92 4.69% 2.17%
Plaquenil 1 57 58 2.95% 1.72% 0.7351 0.1008-5.3585 >0.10
No plaquenil 22 916 938 47.78% 2.35%
anti-TNF (infliximab (6), adalimumab (7)) 0 76 76 3.87% 0.00% 0.2545 0.01561-4.14497 >0.10
no anti-TNF (de lege cellen uit dezelfde kolommen) 23 897 920 46.87% 2.50% 1 patient was treated with both infliximab and adalimumab
Cytotoxic (methotrexa te (2), azathioprine (3), leflunomide (5)) 2 227 229 11.67% 0.87% 0.319 0.07536-1.3502 >0.10
No cytotoxic (lege cellen in dezelfde kolommen) 21 746 767 39.07% 2.74% 3 patients were treated with both methotrexat e and azathioprine
Rituximab
yes 0 1 1 0.05% 0.00% 10.5957 0.9295-120.7801 0.0573
no 23 972 995 50.69% 2.31%
Current medication
yes 7 515 572 26.74% 1.34% 0.40 0.165-0.958 <0.05
no 16 458 474 24.04% 3.38%
Underlying
COPD 0 20 20 1.02% 0.00% 0.9899 0.6217-15.7596 >0.10
23 953 976 49.72% 2.36%
Asthma 2 80 82 4.18% 2.44% 1.0616 0.2534-4.448 >0.10
21 893 914 46.56% 2.30%
Diabetes 2 47 49 2.50% 4.08% 1.8406 0.441-7.628 >0.10 (past) use of prednison can be studied additionally
21 926 947 48.24% 2.22%
Heart failure 0 27 27 1.38% 0.00% 0.7371 0.04592-11.8322 >0.10
23 946 969 49.36% 2.37%
Circulation 2 35 37 1.88% 5.41% 2.4685 0.601-10.1387 >0.10
21 938 959 48.85% 2.19%
Hypertension 1 107 108 5.50% 0.93% 0.3737 0.05088-2.7452 >0.10
22 866 888 45.24% 2.48%
Cancer 0 20 20 1.02% 0.00% 0.9899 0.06217-15.7596 >0.10
23 953 976 49.72% 2.36%
Organ involved
Lung 20 820 840 42.79% 2.38% 1.2381 0.3724-4.1165 >0.10
no Lung 3 153 156 7.95% 1.92%
heart 0 115 115 5.86% 0.00% 0.1618 0.009892-2.645 >0.10
no heart 23 858 881 44.88% 2.61%
CNS 1 118 119 6.06% 0.84% 0.335 0.04557-2.426 >0.10
no CNS 22 855 877 44.68% 2.51%
Sarcoid age
COVID positive 55.3 ± 6.0 years
COVID negative 55.0±10. 8 years
COVID uncertain 50.5 ± 11.0 years
COVID outcome Home Hospital ICU Vent
Sarc 20 3 0 0.00%
Sarc ≥ 5 yr 15 678 693 70.14% 2.16% 0.912 0.3758-2.2141 >0.10
Sarc < 5 yr 7 288 295 29.86% 2.37% 8 unknown
988
Roommates with COVID-19
yes 11 30 41 4.12% 26.83% 21.3516 10.0247-45-4768 <0.0001
no 12 943 955 95.88% 1.26%
996
Work in healthcare
Yes 4 99 103 10.34% 3.88% 1.8252 0.6331-5.2618 >0.10
No 19 874 893 89.66% 2.13%
996
COVID positive Home Hospital Perce nt on drug Percent treate d in hospit al If in hospital, considered
bad outcome
Hazard ration for
Prednisone Hospitalization
Yes 4 0 4 17.39% 0.00% 0.5714 0.03487-9.3644 >0.10
No 16 3 19 82.61% 15.79%
Prednisone ≥ 10 mg 2 0 2 50.00% 0.00% TOO SMALL
Prednisone < 10mg 2 0 2 50.00% 0.00%
Infliximab there were no COVID - 19 positive patients who were treated with infliximab
Plaquenil
Yes 1 0 1 4.35% 0.00% 1.6428 0.1236-21.835 >0.10
No 19 3 22 95.65% 13.64%
Cytotoxic
yes 2 0 2 8.70% 0.00% 1.0476 0.06994-15.6914 >0.10
no 18 3 21 91.30% 14.29%
Rituximab
none of the COVID-19 positive patients was treated with rituximab