Table 2.
Main results of the identified SNPs
| SNP | Chr | Position | Locus | EA/ OA |
Closest gene |
Discovery sample |
Replication sample |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMD | BS | Bivariate | UKB for BMD |
deCODE for BS |
Bivariate | ||||||||||
| Beta | p | Beta | p | p | Beta | p | Beta | p | p | ||||||
| rs7575512 | 2 | 235210293 | 2q37.1 | T/C | ARL4C | 0.049 | 0.02 | 0.132 | 3.26 × 10−10 | 1.49 × 10−9 | 0.009 | 0.06 | 0.045 | 0.03 | 0.05 |
| rs1040724 | 6 | 161575543 | 6q26 | T/C | AGPAT4 | 0.115 | 4.01 × 10−5 | 0.140 | 3.95 × 10−7 | 1.95 × 10−8 | 0.008 | 0.05 | 0.005 | 0.75 | 0.03 |
Physical position is based on the human genome GRCH37 assembly
Chr chromosome, EA effect allele, OA other allele, Beta the regression coefficient of the effect allele, Closest gene the closest gene to which the SNP mapped