TABLE 3:
miRNAs associated with TLR regulation and major depressive disorder
| Toll-like receptor (Nejad C et al 2018) | Major depressive disorder (Lopez JP et al. 2018) | ||||
|---|---|---|---|---|---|
| miRNA | TARGET | RESPONSE | miRNA | SOURCE | EXPRESSION |
| TLR signaling proteins | TLR-responsive miRNAs | ||||
| Let-7b/e/i, miR-146b, miR-181a | TLR4 | Botha | Let-7b | Whole blood | downregulated |
| miR-21, miR29a | TLR7/8 | Pro-inflammatory | miR-124 | PBMC | downregulated |
| miR-146b, miR-155, miR-203 | MyD88 | Anti-inflammatory | Let-7e, miR-146a, miR-155 | PBMC, monocytes | downregulated |
| miR-146a/b | IRAK1/2 | Anti-inflammatory | MDD-specific miRNAs | ||
| miR-146a | IRAK4 | Anti-inflammatory | Let-7b/c | Whole blood | downregulated |
| miR-124, miR-146a/b | TRAF6 | Anti-inflammatory | miR-132 | Whole blood | upregulated |
| miR-155 | TAB2/3 | Anti-inflammatory | miR-34b-5p, miR-34c-5p | Blood leukocytes | upregulated |
| miR-9, miR-124, miR-155 | p65 NF-κB | Anti-inflammatory | miR-320a | Plasma | downregulated |
| TLR PAMPs | miR-16 | CSF | downregulated | ||
| miR-146 | HMGB-1 | Anti-inflammatory | miR-221-3p, miR-34a-5p, Let-7d-3p | Serum | upregulated |
| TLR Negative Regulators | MDD-specific miRNAs- Postmortem | ||||
| miR-19 | ZBTB16 | Pro-inflammatory | miR-185 | APC | upregulated |
| miR-19, miR-221 | TNFAIP3 | Botha | miR-508-3p, miR-152-3p | APC | downregulated |
| miR-19, miR-155, miR-221/222 | SOCS1 | Pro-inflammatory | miR-1202 | VPC | downregulated |
| Proinflammatory Cytokines | miR-511, miR-340 | Basolateral amygdala | upregulated | ||
| miR-146a, miR-155 | IL-8 | Anti-inflammatory | miR-326 | Midbrain | downregulated |
| Let-7a/b, miR-181a, miR-223 | IL-6 | Botha | miR-34a | ACC | downregulated |
| miR-19a, m R-125b, miR-155 | TNF | Botha | miR-218 | VPC | downregulated |
| miR-146a-5p, miR-146b-5p, miR-24-3p, miR-425-3p | VPC | upregulated | |||
Both: anti-inflammatory and pro-inflammatory
Abbreviations- TLR: toll-like receptor; MDD: major depressive disorder; MyD88: myeloid differentiation primary response protein 88; IRAK (1,2,4): interleukin receptor-associated kinase; TRAF6: tumor necrosis factor receptor-associated factor 6; TAB (2/3): TGFβ-activated kinase 1 binding protein 2/3; NF-κB: nuclear Factor kappa-light-chain-enhancer of activated B cells; HMGB-1: high mobility group box 1; ZBTB16: Zinc Finger And BTB Domain Containing 16; TNFAIP3: tumor necrosis factor alpha induced protein 3; SOCS1: Suppressor of cytokine signaling 1; IL-6: interleukin 6; IL-8: interleukin 8; TNF: tumor necrosis factor; PBMC: peripheral blood mononuclear cells; CSF: cerebrospinal fluid; APC: anterior prefrontal cortex; VPC: ventrolateral prefrontal cortex; ACC: anterior cingulate cortex