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. 2021 Jan 11;11:591773. doi: 10.3389/fphar.2020.591773

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Copyright © 2021 Bollmann, Werner, Jaron, Bruns, Wache, Runte, Boknik, Kirchhefer, Müller, Buchwalow, Rothemund, Neumann and Gergs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiovascular stress by lipopolysaccharide (LPS) or β-adrenergic stimulation. Cardiac function was determined by echocardiography under basal conditions and after stress induction. (A) Time dependent effect of LPS or NaCl as control on left ventricular ejection fraction (EF) in WT and PP2C-TG. Ordinate: relative change in ejection fraction (pre LPS values = 1). Abscissa: hours after LPS injection. (B) Time dependent effect of LPS or NaCl on the flow through the aorta measured as velocity time integral (VTI) by Pulsed wave Doppler echocardiography of WT or PP2C-TG. (C) Intraventricular septum thickness (IVST) of WT or PP2C-TG. Mice were injected intraperitoneal with isoproterenol (ISO) or NaCl as control and always 5 min thereafter echocardiography was performed. Ordinate: IVST in mm. Abscissa: days of drug treatment. ★p < 0.05 vs. WT; ⁺ p < 0.05 vs. NaCl.