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Deacetylation mechanism catalyzed by sirtuins. The cofactor NAD+ interacts with acyl lysine substrates to form an intermediate (not shown here) and releases the nicotinamide as a by-product. Further with the help of conserved catalytic His residue, sirtuin decomposes the intermediate to generate deacetylated lysine and the 2′-O-acyl ADPR (OAADPR).
