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. 2021 Jan 12;11:598353. doi: 10.3389/fphar.2020.598353

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Copyright © 2021 Lin, Lin, Yang, Lu, Sun, Sun, Meng, Chi and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SGLT1 inhibition relieved myocardial fibrosis and apoptosis in diabetic rat hearts (n = 10). (A–B) HE and Masson’s Trichrome staining of myocardial tissue. (C–D) Relative protein levels of collagen I and collagen III. (E) Apoptotic rate of cardiomyocytes measured by TUNEL staining. (F) Bax, bcl2, and caspase-3 protein expression in rats. (G) RT-PCR analysis of bax, bcl2, and caspase-3 in tissues. *p < 0.05 control; ^# p < 0.05 vs. DCM. Experiments were performed in triplicate.