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SGLT1 inhibition relieved apoptosis in H9C2 cells. H9C2 cells were treated with 10, 20, or 40 µM mizagliflozin for 24 h, followed by treatment with or without 30 mmol/L HG. (A) Relative protein levels of bax, bcl2, and caspase-3. (B) RT-PCR analysis of bax, bcl2, and caspase-3. (C) Caspase-3 activity in H9C2 cells. (D) Apoptotic rate of H9C2 cells measured by TUNEL staining. *p < 0.05 vs control; # p < 0.05 vs DCM. Experiments were performed in triplicate.
