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. 2021 Jan 12;11:598353. doi: 10.3389/fphar.2020.598353

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Copyright © 2021 Lin, Lin, Yang, Lu, Sun, Sun, Meng, Chi and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SGLT1 upregulation aggravated apoptosis induced by HG. (A) SGLT1 protein expression following successful transfection of SGLT1 into H9C2 cells. (B) RT-PCR analysis of SGLT1. (C) The expression of apoptosis-related specific markers (bax, bcl2, caspase-3). (D) Relative mRNA levels of bax, bcl2, and caspase-3. (E) Caspase-3 activity in H9C2 cells. (F) Apoptotic rate of H9C2 cells measured by TUNEL staining. *p < 0.05 compared with the control group; ^# p < 0.05 compared with HG group. Experiments were performed in triplicate.