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. 2021 Jan 12;11:598353. doi: 10.3389/fphar.2020.598353

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Copyright © 2021 Lin, Lin, Yang, Lu, Sun, Sun, Meng, Chi and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SGLT1 knockdown attenuated apoptosis induced by HG. (A–B) Specific siRNAs targeting SGLT1 were used to knockdown SGLT1, as confirmed by western blotting and RT-qPCR. (C) The apoptotic rate was determined by TUNEL assay. (D–E) The expression of bax, bcl2, and caspase-3 in H9C2 cells were detected by RT-PCR and western blot analyses. (F) Caspase-3 activity in H9C2 cells. *p < 0.05 compared with the control group; ^# p < 0.05 compared with HG group. Experiments were performed in triplicate.