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. 2021 Jan 11;11:580064. doi: 10.3389/fphar.2020.580064

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Copyright © 2021 Liu, Liu, Gu, Liu, Li, Yang, Zheng, Li, Wu, Wu, Zhang, Li, Yang, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of C + R + I pretreatment on pathological changes in lung tissues of LPS-induced ALI (original magnification ×200); (A) Control; (B) LPS; (C) 1 mg/kg dexamethasone + LPS; (D) C + R + I low dose + LPS; (E) C + R + I middle dose + LPS, and; (F) C + R + I high dose + LPS. Data were expressed as means ± SEM of three independent experiments. *: p < 0.05, **p < 0.01 as compared to the LPS group without C + R + I, #p < 0.05, ##p < 0.01 as compared to the normal control group without C + R + I. Effects of C + R + I on the inflammatory cell infiltration in LPS-induced ALI.