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. 2021 Jan 11;11:580064. doi: 10.3389/fphar.2020.580064

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Copyright © 2021 Liu, Liu, Gu, Liu, Li, Yang, Zheng, Li, Wu, Wu, Zhang, Li, Yang, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C, R and I have multiple targets (A–C) C had a good affinity with the inhibitor binding site of iNOS and MPO (D–E) R can target iNOS, ERK and COX-2 (G–I) I can interact with iNOS, MPO and HO-1.