Fig. 3.

Assessment of the risk of bias in vivo studies at an individual level, according to SYRCLE's ROB tool. *In two trial both methods (in vitro and in vitro studies) were investigated. *Part B (in vivo studies). **exclusively in vivo trial. Allocation sequence generation; 2) Baseline characteristics; 3) Allocation concealment; 4) Random Housing; 5) Blinding of personnel & participants; 6) Random outcome assessment; 7) Outcome assessor blinding; 8) Incomplete outcome data; 9) Selective outcome reporting; 10) Other sources of bias; 11) Scores. Low risk of bias; High risk of bias; Unclear risk of bias. *.