Table 3.
Key Mean Pharmacokinetic Parameters of Dexanabinol
| Dose (mg/kg) |
Dose Fold Increase | Plasma |
t
1/2 (h)b |
CSF | ||||
|---|---|---|---|---|---|---|---|---|
|
C
max (ng/mL)a |
C max Fold Increase |
t
max (h)b |
AUC0-4h (ng.h/mL)a |
AUC0-4h Fold Increase |
C
max (ng/mL)c |
|||
| 2 | 1.0 | 204 (15.3) | 1.0 | 0.5 | 475 (24.1) | 1.0 | 2.2 | 1.1 (30.3) |
| 4 | 2.0 | 387 (23.1) | 1.9 | 1.0 | 881 (11.6) | 1.9 | 1.7 | 2.5 (34.2) |
| 8 | 2.0 | 813 (14.0) | 2.1 | 0.5 | 1890 (19.6) | 2.1 | 2.3 | 6.3 (41.5) |
| 16 | 2.0 | 2885 (22.6) | 3.5 | 0.5 | 5750 (29.3) | 3.0 | 1.8 | 72 (58.9) |
| 24 | 1.5 | 4226 (45.1) | 1.5 | 0.5 | 10 800 (18.3) | 1.9 | 3.4 | 44 (71.6) |
| 28 | 1.2 | 7018 (26.8) | 1.7 | 0.5 | 15 400 (17.1) | 1.4 | 1.7 | 38 (47.8) |
| 36 | 1.3 | 20 139 (45.5) | 2.9 | 0.5 | 38 300 (35.5) | 2.5 | 2.0 | 114 (74.9) |
Abbreviations: AUC, area under the concentration-time curve for 0 to 4 h after end of infusion; Cmax, maximum measured concentration; CV, coefficient of variation; tmax, time from end of infusion to maximum concentration.
aGeometric means (CV%) reported.
bMedian.
cArithmetic means (CV%) reported.