Table 4.
Number of Cycles, PFS and Best Response by Dose Level (N = 24)
| Dose (mg/kg) |
No. Cycles | PFS (Days) | Best Response | No. Evaluable | |||||
|---|---|---|---|---|---|---|---|---|---|
| Median | Range | Median | Range | CR | PR | SD | PD | ||
| 2 | 1.75 | 1–2 | 48 | 29–55 | 0 | 0 | 0 | 3 | 3 |
| 4 | 1.75 | 1.75–2.25 | 60 | 49–61 | 0 | 0 | 0 | 3 | 3 |
| 8 | 1 | 1–1.75 | 27 | 21–49 | 0 | 0 | 0 | 3 | 3 |
| 16 | 1 | 1–4 | 27 | 21–109 | 0 | 0 | 1 | 2 | 3 |
| 24 | 1.75 | 1–2 | 49 | 28–55 | 0 | 0 | 0 | 3 | 3 |
| 28 | 3 | 2.25–4 | 79 | 60–103 | 0 | 0 | 2 | 1 | 3 |
| 36 | 1.75 | 1–8 | 51 | 24–225 | 0 | 0 | 2 | 4 | 6 |
Abbreviations: CR, complete response; PD, progressive disease; PFS, progression-free survival; PR, partial response; SD, stable disease.