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. 2020 May 27;12(11):870–880. doi: 10.1093/jmcb/mjaa023

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© The Author(s) (2020). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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The m¹A motif is enriched in SG mRNAs. (A) TRMT6/61A methyltrasferase binds free RNAs in heat-shocked cytosol of HeLa cells (Alriquet et al., 2019). (B) tRNA, TΨC arm of tRNA where adenine 58 (A*) is N1-methylated by TRMT6/61A. mRNA, mRNA motif (red) targeted by TRMT6/61A for adenine N1-methylation (Li et al., 2017). This study, motif used here to predict mRNA targets of TRMT6/61A-mediated adenine N1-methylation. (C) Fraction of mRNAs enriched or depleted in SGs (Khong et al., 2017) and containing the m¹A motif: 150 out of 1434 and 60 out of 1353, respectively. Control, mRNA set neither enriched nor depleted in SG; ***P < 0.001, chi-square analysis. (D) The number of m¹A motifs in the mRNAs analyzed in Figure 1C. (E) Cumulative fraction of mRNAs at different transcript size cutoff.