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. 2021 Jan 27;10:592884. doi: 10.3389/fonc.2020.592884

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Copyright © 2021 Ma, Huang, Huang, Li, Li, Huang, Zhong and Cao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of circ_0014717 shRNA on hepatocellular carcinoma (HCC) cell growth was reversed by B-cell translocation gene 2 (BTG2). (A) Circ_0014717 expression in Hep3B cells. Hep3B cells were infected with circ_0014717 shRNA-1, 2 or 3 for 48 h. (B–D) BTG2 protein and mRNA expression in Hep3B cells. (E) CCK-8 assay was carried out to evaluate Hep3B cell viability. Hep3B cells with decreased circ_0014717 were transfected with BTG2 vector or EV. (F) Apoptosis assay was used to assess cell apoptosis. (G) Colony formation assay was conducted to test Hep3B cell colony formation capacity. (H) Transwell invasion assay was used to detect Hep3B cell invasion. (I) Mechanism diagram of circ_0014717/miR-668-3p/BTG2 in HCC progression. *P < 0.05.