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Model simulation of sequential therapies using various nab-paclitaxel doses and schedules. Top row (A–C) represents the median tumor volume after 8 weeks of each dose regimen; middle row (D–F) represents the median CD8+ T cell density at week 8; and bottom row (G–I) represents the median Treg density in the tumor at week 8. Administration of nab-paclitaxel starts on day 1 (A, D,G), week 2 (B, E, H), and week 4 (C, F, I) on reaching initial tumor diameter.
