Table 4.
Factors independently associated with ICU mortality in automatic and clustering models (automatic model: generalized linear model [GLM] with important variables according to information value analysis for ICU mortality; A, B and C Phenotypes: GLM models with important variables according to information value analysis for each cluster)
| Automatic model | A phenotype | B phenotype | C phenotype | ||||
|---|---|---|---|---|---|---|---|
| Variablesa | OR (95%CI) | Variablesa | OR (95%CI) | Variablesa | OR (95%CI) | Variablesa | OR (95%CI) |
| Age 56–66y | 2.39 (1.68–3.41) | Age > 61y | 4.37 (2.16–9.31) | Age 58–66 y | 2.79 (1.40–5.76) | Age 56–73y | 2.22 (1.42–3.07) |
| Age > 66–73y | 3.51 (2.44–5.08) | Age > 66 y | 5.75 (3.10–11.1) | Age 74–78y | 3.79 (2.14–6.79) | ||
| Age > 73 | 5.97 (4.05–8.82) | Age > 78y | 21.6 (6.58–99.8) | ||||
| APACHE II 15–19 | 1.88 (1.36–2.63) | APACHE II > 14 | 2.21 (1.20–4.10) | APACHEII > 16 | 1.84 (1.21–2.80) | ||
| APACHE II > 19 | 1.67 (1.15–2.45) | ||||||
| SOFA 3–7 | 1.57 (1.09–2.27) | SOFA > 4 | 2.20 (1.19–4.10) | ||||
| SOFA 7–8 | 1.66 (1.03–2.67) | ||||||
| SOFA > 8 | 1.70 (1.05–2.77) | ||||||
| COPD | 1.50 (1.01–2.24) | COPD | 2.30 (1.03–5.10) | ||||
| > 3 infiltrates | 1.72 (1.02–1.90) | No infiltrates | 0.15 (0.02–0.74) | ||||
| LDH > 500 U/L | 1.30 (1.02–1.66) | LDH > 800 U/L | 2.66 (1.22–5.84) | LDH > 500 U/L | 1.56 (1.03–2.38) | ||
| PCT > 0.45 ng/mL | 1.36 (1.01–1.86) | ||||||
| Lactate > 2.2 mmol/L | 1.78 (1.34–2.37) | Lactate 1–1.7 mmol/L | 3.13 (1.14–10.2) | Lactate > 2.0 mmol/L | 1.90 (1.34–2.87) | ||
| Lactate > 1.7 mmol/L | 4.04 (1.45–13.4) | ||||||
| D Dimer > 4000 ng/mL | 1.44 (1.10–1.89) | D Dimer > 2000 ng/mL | 2.46 (1.23–4.94) | D Dimer < 300 ng/mL | 0.07 (0.01–0.33) | D Dimer > 3000 ng/mL | 1.46 (1.04–2.05) |
| Ferritin 1700–3350 ng/mL | 1.65 (1.28–2.12) | Ferritin > 1600 ng/mL | 2.23 (1.154.36) | Ferritin > 3000 ng/mL | 2.09 (1.06–4.21) | ||
| Ferritin > 3350 | 3.24 (1.82–5.84) | ||||||
| PaO2/FiO2 > 140 | 0.65 (0.50–0.84) | PaO2/FiO2 > 150 | 0.60 (0.40–0.88) | ||||
| GAP-UCI > 8 days | 1.61 (1.00–2.60) | GAP-UCI > 8 days | 3.97 (1.81–9.4) | ||||
| AKI | 2.53 (1.94–3.32) | AKI | 3.41 (1.72–6.84) | AKI | 2.11 (1.22–3.64) | AKI | 2.05 (1.45–2.91) |
| Hydroxychloroquine | 0.33 (0.12–0.87) | ||||||
| Myocardial dysfunction | 3.16 (1.14–8.78) | ||||||
| Hematologic Dis | 3.01 (1.22–7.97) | ||||||
| Coronary Dis | 2.71 (1.25–6.27) | ||||||
OR Odds ratio, CI Confidence interval, APACHE II Acute Physiology and Chronic Health Evaluation II, SOFA Sequential Organ Failure Assessment, COPD Chronic obstructive pulmonary disease, LDH D-Lactate dehydrogenase, PCT Procalcitonin, GAP-UCI Time in days from symptoms onset and ICU admission, PaO2/FiO2 Partial pressure arterial oxygen/fraction of inspired oxygen, AKI acute kidney injury
aCorresponds to categorized variables independently associated with ICU mortality