Table 3.
The Dose Relationships of Psychotropics to Microbial Alpha Diversity Using a Fixed-Effect Model
| Chao1 Index | Shannon Index | PD Whole Tree | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate | SE | P value | Estimate | SE | P value | Estimate | SE | P value | |
| Intercept | 16 795.45 | 1150.777 | <.001 | 5.705573 | 0.358251 | <.001 | 58.10886 | 4.979865 | <.001 |
| Imipramine-eq | −2.43114 | 2.29714 | .293 | −0.00052 | 0.000711 | .464 | −0.0015 | 0.00989 | .880 |
| CP-eq | −1.88646 | 1.931047 | .331 | −0.00254 | 0.000595 | <.001* | −0.02644 | 0.00833 | .002* |
| Diazepam-eq | −45.0931 | 60.14956 | .455 | −0.00178 | 0.018621 | .924 | 0.067608 | 0.258189 | .794 |
| HAM-D | 25.90793 | 72.32276 | .721 | −0.01281 | 0.020656 | .537 | −0.01169 | 0.279335 | .967 |
| HAM-A | 60.10727 | 72.99435 | .413 | 0.023183 | 0.020865 | .270 | 0.222334 | 0.281826 | .433 |
| BMI | −93.0798 | 54.45308 | .091 | 0.014021 | 0.016965 | .411 | 0.18641 | 0.235552 | .431 |
Abbreviations: BMI, body mass index; CP, chlorpromazine; -eq, equivalency scale; HAM-A, Hamilton Rating Scale for Anxiety; HAM-D, Hamilton Rating Scale for Depression; PD, phylogenetic diversity.
Repeated covariance type: diagonal; n = 40.
*P < .05.