Table 1.

mRNA expression of GABA_A (GABA_AR) and GABA_B (GABA_BR) receptor subunits in the PFC (BA10), HPC, STR, and CB of CONT and AUD subjects

		GABAAR						GABABR
		α1	α2	α4	α5	α6	δ	1	2
PFC	CONT	1.00 ± 0.04	1.00 ± 0.07	1.00 ± 0.09	1.00 ± 0.11	1.00 ± 0.14	1.00 ± 0.12	1.00 ± 0.05	1.00 ± 0.06
	AUD	0.95 ± 0.04	0.77 ± 0.06*	0.98 ± 0.08	0.95 ± 0.08	0.64 ± 0.06*	0.71 ± 0.05*	0.84 ± 0.04*	0.80 ± 0.03**
HPC	CONT	1.00 ± 0.08	1.00 ± 0.13	1.00 ± 0.11	1.00 ± 0.12	ND	1.00 ± 0.24	1.00 ± 0.07	1.00 ± 0.12
	AUD	0.86 ± 0.09	0.84 ± 0.07	1.00 ± 0.07	0.89 ± 0.07		0.67 ± 0.10	0.87 ± 0.05	1.00 ± 0.06
STR	CONT	1.00 ± 0.16	1.00 ± 0.15	1.00 ± 0.10	1.00 ± 0.16	1.00 ± 0.13	1.00 ± 0.21	1.00 ± 0.06	1.00 ± 0.15
	AUD	0.82 ± 0.07	0.81 ± 0.08	1.07 ± 0.12	0.57 ± 0.32	1.07 ± 0.12	1.12 ± 0.21	0.89 ± 0.06	0.81 ± 0.11
CB	CONT	1.00 ± 0.11a	1.00 ± 0.11/1.00 ± 0.15	1.00 ± 0.13	1.00 ± 0.15	1.00 ± 0.09†	1.00 ± 0.08†	1.00 ± 0.05 0.85 ± 0.05*	1.00 ± 0.05 0.89 ± 0.04
	AUD	0.92 ± 0.07	0.66 ± 0.08*/0.65 ± 0.08*	1.11 ± 0.15	1.40 ± 0.24	0.99 ± 0.13	0.75 ± 0.07*

Abbreviations: AUD, alcohol use disorder; CB, cerebellum; CONT, control; HPC, hippocampus; PFC, prefrontal cortex; STR, striatum.

^a These data were part of our previously published study and have been revised to include only the males of the same cohort (Gatta et al., 2017). In cerebellum, similar results were obtained with 2 different set of primers targeting GABA_AR α ₂ subunit (see supplementary Table 2). Values are mean ± SEM of 19–20 samples per group *P < .05, **P < .01. Student’s t test vs control. α ₆ mRNA levels were not detectable in the HPC in our experimental conditions (ND).