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. 2020 Sep 25;24(2):142–157. doi: 10.1093/ijnp/pyaa075

Figure 1.

Figure 1.

Anti-amnesic effect of Memantine (a, c, e, g) and FENM (b, d, f, h) on Aβ 25-35-induced learning impairments in mice: (a–b) spontaneous alternation performance, (c–d) passive avoidance, and (e–h) object recognition test. Animals received Memantine or FENM (0.1–10 mg/kg IP) 30 minutes before the Y-maze test session, passive avoidance training session, or session 2 of the object recognition test. For the object recognition test, exploration preferences are calculated with the duration of contacts in session 2 with 2 identical objects (e–f) and in session 3 with a novel object (g–h). Data show mean ± SEM (a–b, e–h) and median and interquartile range (c–d). ANOVA: F(6,83) = 2.62, P < .05 (a); F(6,89) = 4.94, P < .001 (b). Kruskal-Wallis ANOVA: H = 23.4, P < .001 (c); H = 19.5, P < .01 (d). *P < .05, **P < .01, ***P < .001 vs (Sc.Aß+V)-treated group; #P < .05, ##P < .01 vs (V+Aβ 25–35)-treated group; Dunnett’s test (a–b), Dunn’s test (c–d). °P < .05, °°P < .01, °°°P < .001 vs 50% level, 1-sample t test (g–h).