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. 2020 Sep 25;24(2):142–157. doi: 10.1093/ijnp/pyaa075

Figure 4.

Figure 4.

Protective effects of Memantine and FEN administered at 0.3 mg/kg IP on Aβ 25-35-induced learning impairments: spatial reference memory in the water-maze in mice. (a) Acquisition of Veh-treated and Aβ 25-35-injected animals. (b) Acquisition of animals receiving Memantine or FENM, 0.3 mg/kg IP, after the Aβ 25–35 peptide on day 1 and started training on day 8 (neuroprotection). (c) Time spent in the training (T) or the others (o) quadrants for each experimental group. °°P < .01, °°°P < .001 vs 15 s; 1-sample t test; ***P < .001 vs o quadrants; Student ’s t test.