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. 2020 Sep 25;24(2):142–157. doi: 10.1093/ijnp/pyaa075

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© The Author(s) 2020. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Protective effects of Memantine and FENM administered at 0.3 mg/kg IP on Aβ _25-35-induced (a–c) oxidative stress and mitochondrial alteration and (d) Iba-1, (e) GFAP, (f) IL-6, (g) TNFα, (h) Bcl-2, and (i) Bax contents measured by ELISA in the mouse hippocampus. (a–b) Cytochrome c release from mitochondria to the cytosol in cortex extracts. (a) Typical blots showing oxphos-complex IV subunit I mitochondrial marker and cytochrome c labeling. Normalization was done with stain free total protein content in each band. (b) Quantification. (c) Measure of lipid peroxidation level in mouse cortex extracts. ELISA assays were done 16 days after ICV injection (d–e, h–i) or 5 days after ICV injection (f–g). (j) Bax/Bcl-2 ratio. ANOVA: F_(3,31) = 3.05, P < .05 (b). F_(3,21) = 4.33, P < .05; F_(3,22) = 2.53, P > .05 (d); F_(3,21) = 1.06, P > .05 (e); F_(3,31) = 3.06, P < .05 (f); F_(3,31) = 2.10, P > .05 (g); F_(3,22) = 2.00, P > .05 (h); F_(3,22) = 3.37, P < .05 (i); F_(3,22) = 0.763, P > .05 (j). *P < .05, ***P < .001 vs (V+V)-treated group; #P < .05 vs (V+Aβ _25–35)-treated group; Dunnett’s test.