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. 2020 Sep 25;24(2):142–157. doi: 10.1093/ijnp/pyaa075

Figure 7.

Figure 7.

Protective effects of Memantine and FENM administered at 0.3 mg/kg IP on the astroglial reaction in the hippocampus of Aβ 25-35-treated mice using GFAP immunolabeling: (a–e) stratum radiatum, (f–j) molecular layer, and (k–o) polymorph layer with (a–d, f–i, k–n) typical immunofluorescence micrographs (blue: DAPI, green: GFAP) and (e, j, o) quantifications. Coronal 25-µm-thick sections were stained with anti-GFAP antibody and 3 areas of the hippocampus analyzed as shown in Figure 8g. Scale bar (a) = 50 µm. ANOVA: F(3,22) = 5.06, P < .01 (e); F(3,23) = 4.50, P < .05 (j); F(3,23) = 3.24, P < .05 (o). *P < .05, ***P < .001 vs the (V+V)-treated group; #P < .05, ##P < .01 vs the (Aβ 25–35+V)-treated group; Dunnett’s test.