Table 2.

Effects of a High Dose of Memantine and FENM on Learning in Mice

Test	Saline	Memantine	FENM
		(10 mg/kg i.p.)	(10 mg/kg i.p.)
Spontaneous alternation
Alternation (%)	70.8 ± 3.8	48.8 ± 3.0***	63.7 ± 4.2
Arm entries	30.8 ± 1.3	28.2 ± 2.9	32.7 ± 3.4
Passive avoidance
Step-through latency (s)	300 (115–300)	26 (12–40)***	144 (103–281)
N	8	9	7

Abbreviations: FENM, fluoroethylnormemantine.

ANOVA: F_(2,23) = 10.3, P < .001 for alternation; F_(2,23) = 0.728, P > .05 for arm entries. Kruskal-Wallis ANOVA: H = 11.4, P < .01 for step-through latency.

***P < .001 vs saline, Dunnett’s or Dunn’s test.