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. 2021 Jan 16;27:37–49.

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Copyright © 2021 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Intraocular pressure profiles in rats treated with SA-2, Travoprost and SA2 NPs eye drops. Effect of single dose topically administered SA-2 (75 mM) and SA-2 NPs (1%, 2.5 mM of SA-2) eye drop formulated in PBS in normotensive (A–C, n = 3, Sprague Dawley) and the Morrison intraocular pressure (IOP) elevation model (D, n = 3,, Brown Norway) rats at 3, 6, 24, 48, and 72 h post dose. Travoprost (0.004%) was used as positive control. *p<0.001 and #p<0.05 (rank-sum test), n = 3 rats per group. Contralateral eyes were used as controls. Values are expressed in mean ± standard error of the mean (SEM).