Figure 6.

Assessment of aqueous humor dynamics in the mice treated with SA-2 NPs eye drops. A: The effect of SA-2 NPs (1%) topical eye drop administration in adenovirus 5 (Ad5) viral vector expressing mutated human TGFβ^c226s/c228s (Ad5.TGFβ-2) induced ocular hypertensive (OHT) mice eyes (n = 5) at various time points post dose. The decrease in intraocular pressure (IOP) was statistically significant up to 30 h. *p<0.001, one-way analysis of variance (ANOVA), followed by Dunnett’s post-hoc paired comparison. B: SA-2 NPs increased aqueous humor outflow facility in OHT mice, *p<0.002, paired t test. C: SA-2 NPs caused a decrease in episcleral venous pressure (Pe), **p<0.001, paired t test. Values are expressed in mean ± standard error of the mean (SEM).