FIGURE 3.

INK128 extends follicle development for 12 weeks in the rOvary of G2 Terc ^−/− mice. (a) Follicle development in the rOvary of G2 Terc ^−/− mice treated with or without INK128 for 8 or 12 weeks following transplantation of PGC aggregates. Representative images showing histology of rOvary sections by H&E staining. Scale bar = 100 μm. (b) Number of follicles at various developmental stages in the rOvary 8 or 12 weeks after transplantation. (c) Levels in the serum of follicle‐stimulating hormone (FSH), anti‐Müllerian hormone (AMH), and estradiol (E2) of recipient mice treated with (+) or without (−) INK128 following transplantation of PGCs for 8 or 12 weeks. G2 Terc ^−/− mice at the age of 10 weeks served as young control. G2 Terc ^−/− mice at 22 weeks old and those with a bilaterally ovariectomized (OE) served as negative controls of transplants. Each aggregate was transplanted beneath the kidney capsule of a bilaterally ovariectomized recipient mouse. Mean ± SEM. n ≥ 3. *p < 0.05, **p < 0.01, ***p < 0.001